在ICU治疗COVID-19肺炎的侵入性通风治疗后六个月的放射性外观和肺功能:一项观察后续研究
Ylva Konsberg1, Pawel Szaro2,3, Anders Aneman1,4,5,6
1Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
PloS one
|September 1, 2023
概括
需要重症监护的COVID-19幸存者经常经历持久的肺损伤. 出院六个月后,CT扫描显示持续的异常,肺功能测试显示肺体积减少和气体交换受损,成像和功能之间的相关性较弱.
科学领域:
- 肺部病理学 肺部病理学
- 关键护理医学 关键护理医学
- 放射学 放射学是一门学科.
背景情况:
- 进入重症监护室 (ICU) 进行侵入性通风的COVID-19患者可能会出现呼吸功能连续症.
- 关于这些患者的长期放射学和功能性肺部变化的数据有限.
研究的目的:
- 在COVID-19ICU幸存者中,在医院出院6个月后调查放射性肺部外观和肺功能.
- 在随访时评估CT发现与肺功能之间的关联.
主要方法:
- 一个单一中心前性观察研究跟踪了86名COVID-19ICU患者.
- 胸部计算机断层扫描 (CT) 和肺功能测试 (PFT) 在出院6个月后进行.
- CT严重性得分和PFTz-得分之间的相关性使用斯皮尔曼的rho.
主要成果:
- 78/85名参与者有病态CT发现,最常见的是纤维带 (91%).
- 在34%的参与者中观察到限制性PFT模式,66%的参与者减少了肺部对一氧化碳 (DLCO) 的扩散能力.
- 在CT严重性得分和强迫生命能力 (FVC),DLCO和气泡体积 (VA) z-score之间发现了弱相关性.
结论:
- 大多数COVID-19 ICU幸存者在出院6个月后表现出持续的放射性异常和肺功能受损.
- 图像扫描结果与肺功能之间的相关性很弱.
- 长期后续研究是必要的,以了解肺功能在这个人群的轨迹.
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