蚊子直接食2型登革热病毒感染者,揭示了人类传染性的动态
Louis Lambrechts1, Robert C Reiner2, M Veronica Briesemeister3
1Institut Pasteur, Université Paris Cité, CNRS UMR2000, Insect-Virus Interactions Unit, Paris, France.
PLoS neglected tropical diseases
|September 1, 2023
概括
感染登革热病毒 (DENV) 的轻症患者在患病的第二天对蚊子最容易传染. 在蚊子中病毒血量较高和化时间较长增加了DENV传播的概率.
科学领域:
- 医学昆虫学 医学昆虫学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 人与蚊子之间的登革热病毒 (DENV) 传播对流行病学至关重要,但人们对其了解甚少.
- 病毒水平是决定DENV传播的主要因素,但其他因素也影响着传染性.
- 之前的研究缺乏自然感染人类的直接蚊子养数据.
研究的目的:
- 调查影响DENV从轻度疾病的人类传播到Aedes蚊子的因素.
- 根据病毒病,疾病日和外部潜伏期来量化DENV传播的概率.
主要方法:
- 在秘鲁伊基托斯,对自然感染DENV的个体进行了直接蚊子养研究.
- 在蚊子唾液中使用传染性病毒分析了DENV-2传染概率,即血食后7-16天.
- 排除了在食时无法检测到的病毒血症的参与者.
主要成果:
- DENV传播的概率与病毒性水平和外部化时间正相关.
- 传染概率在症状出现后的第二天达到峰值,然后下降.
- 轻度患病的个体表现出不同的传染性,尽管病毒血量水平相似.
结论:
- 疾病的第二天是轻度DENV感染的人对蚊子最具传染性.
- 了解人类传染性变异对于流行病学模型和DENV控制至关重要.
- 直接食蚊子的研究为疾病传播动态提供了关键数据.
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