在感染Paranosema locustae的Locusta migratoria (Orthoptera: Acrididae) 中发生的分子和生化变化
Huihui Zhang1,2, Kun Yang3, Han Wang1,2
1International Research Center of Cross-Border Pest Management in Central Asia, Xinjiang Key Laboratory of Special Species Conservation and Regulatory Biology, College of Life Sciences, Xinjiang Normal University, Xinyi Road, Urumqi, Xinjiang Province 830054, China.
Journal of insect science (Online)
|September 1, 2023
概括
帕拉诺西马虫感染会改变迁徙虫的能量代谢,从糖转变为脂质和蛋白质. 这种加速的新陈代谢有助于病原体的生存和虫的死亡率.
科学领域:
- 昆虫学 昆虫学是一门学科.
- 寄生虫学的寄生虫学
- 生物化学 生物化学
背景情况:
- 微粒体是真核细胞内寄生虫,感染多种不同的宿主.
- 帕拉诺西马虫 (Paranosema locustae) 特别针对的是虫 (Orthoptera),并用于生物控制.
- P. locustae表现出缓慢作用的效果,需要了解其致病机制.
研究的目的:
- 研究P. locustae感染对Locusta migratoria能量代谢的影响.
- 为了确定对P. locustae感染的代谢反应的性别特异性差异.
- 阐明宿主新陈代谢和病原体生命周期进展之间的关系.
主要方法:
- 迁徙虫感染P. locustae. 的感染.
- 随着时间的推移,分析能源利用情况 (糖,脂质,蛋白质).
- 基于双重质量标签的定量蛋白质组学来识别改变的代谢蛋白质.
主要成果:
- 在能量代谢变化方面没有观察到显著的性别差异.
- 起初,L. migratoria利用了糖;后来,随着感染的进展,脂质和蛋白质被消耗.
- 蛋白质组学揭示了大多数与代谢相关的蛋白质的上调,表明宿主代谢加速.
- 高死亡率发生在感染后15天左右,与先进的代谢转变相关.
结论:
- 感染P. locustae加速了L. migratoria的宿主新陈代谢,支持了病原体的发展.
- 观察到的代谢变化对于病原体的生命周期和最终宿主死亡至关重要.
- 了解这些机制可以改善P. locustae用于虫控制的应用.
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