一个患有肺腺癌的患者的贝瓦西祖马布诱导的心律失常:一个病例报告
Jing Li1, Furong Zhang2, Yuanyuan Lu2
1Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Medicine
|September 1, 2023
概括
作为癌症治疗的贝瓦西祖马布 (bevacizumab) 可以导致心律失常 (心律失常). 这一案例凸显了在治疗贝瓦西祖马布期间监测心律失常的重要性,即使是单次治疗.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 心脏毒性是用于癌症治疗的血管内皮生长因子抑制剂 (VEGFIs) 的已知副作用.
- 贝瓦西祖马布是一种常见的VEGF抑制剂,已与高血压和血栓形成有关.
- 节律失常是VEGFIs报告不足的一种不良影响.
研究的目的:
- 报告第一个bevacizumab相关心律不整的病例.
- 为了强调接受贝瓦西祖马布治疗的患者需要进行心脏监测.
- 讨论贝瓦西祖马布治疗的潜在心脏风险.
主要方法:
- 一名56岁的肺腺癌患者接受了贝瓦西祖马布单一治疗.
- 患者出现了心室节律失常和心电图变化.
- 节律失常被用阿司匹林和阿米奥达龙治疗,随后进行冠状动脉血管造影.
主要成果:
- 患者的心律失常和症状在阿米奥达龙治疗后得到缓解.
- 心电图 (ECG) 监测恢复正常.
- 冠状动脉扫描显示了最小的冠状动脉狭窄,这表明心律失常是药物诱导的.
结论:
- 这一案例代表了贝瓦西祖马布诱导心律失常的第一例.
- 临床医生应考虑接受贝瓦齐祖马布治疗的患者心律失常的风险,无论是单一治疗还是联合治疗.
- 需要进一步的研究,以阐明贝瓦西祖马布相关心脏毒性的机制.
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