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基于全面的生物信息学分析识别HOXB9,用于预测头部和部状细胞癌的预后

Juanjuan Li¹, Hong Ran^1,2, Xiaoxia Zeng¹

¹Department of Otorhinolaryngology, Longgang Otorhinolaryngology Hospital & Shenzhen Key Laboratory of Otorhinolaryngology, Shenzhen Institute of Otorhinolaryngology, Shenzhen, Guangdong, China.

|September 1, 2023

概括

在头部和部平状细胞癌 (HNSCC) 中,HOXB9的调节升高,与恶性瘤增加和更差的预后相关. 该基因影响免疫细胞透,表明HOXB9是HNSCC.的潜在预后生物标志物和治疗点.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
遗传学是一个遗传学.

背景情况:

头部和部状细胞癌 (HNSCC) 是一种具有复杂分子基础的流行癌症.
了解特定基因在HNSCC进展和免疫反应中的作用,对于开发有效疗法至关重要.

研究的目的:

调查HOXB9表达和HNSCC的预后之间的相关性.
分析HOXB9与HNSCC.免疫细胞透的关联.
探索HOXB9作为HNSCC中的潜在生物标志物和治疗点.

主要方法:

使用了TIMER2.0,GEPIA,TCGA,UALCAN,Kaplan-Meier Plotter,STRING和Cytoscape数据库进行全面的分析.
分析了HNSCC组织与正常组织以及各种临床病理学亚组中的HOXB9表达.
进行了生存分析,基因联合表达分析,功能注释 (GO,KEGG),蛋白质-蛋白质相互作用网络构建和免疫透评估.

主要成果:

在多个数据库中,与正常组织相比,HNSCC组织中的HOXB9mRNA水平显著升高.
在HNSCC中,HOXB9表达与瘤恶性病变正相关,与患者预后负相关.
改变HOXB9表达与各种免疫细胞的差异性透有关,包括aDCs,NK细胞,Th2,DCs,iDCs,中性粒细胞和Th17细胞.

结论:

在HNSCC中,HOXB9作为瘤基因起作用,可能通过调节瘤免疫微环境.
HOXB9被确定为HNSCC的一个有前途的预后生物标志物.
在HNSCC治疗中,HOXB9是潜在的治疗点.

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