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脑卒中后认知障碍与肠道微生物群之间的关联:符合PRISMA的系统审查和元分析

Xiaozhen Hu¹, Yajun Mao¹, Fang Luo²

¹Department of rehabilitation medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China.

|September 1, 2023

概括

脑卒中后认知障碍 (PSCI) 与肠道微生物群的变化有关. 这项研究发现,与健康个体相比,PSCI患者的肠道细菌组成存在显著差异,这表明潜在的肠-大脑轴连接.

科学领域:

微生物组研究的研究.
神经科学是一个神经科学.
胃肠病学胃肠病学

背景情况:

越来越多的证据表明,中风后认知障碍 (PSCI) 和肠道微生物群失调之间存在联系.
了解这种肠-大脑轴连接对于开发新的治疗策略至关重要.

研究的目的:

系统地评估患有PSCI和健康对照个体之间的肠道微生物群差异.
提供有关PSCI肠道微生物群变化的现有证据的全面概述.

主要方法:

进行了相关研究的元分析和系统审查.
搜索的数据库包括PubMed,科学网,Embase,VIP,CNKI和王芳.
聚合结果被用来估计肠道微生物群组成差异.

主要成果:

在分析中包括了9项研究.
在财富指数 (Chao1,ACE) 或Shannon指数中没有观察到显著变化.
与对照组相比,PSCI患者的辛普森指数显著下降.
在菌群 (蛋白质细菌增加),家族 (Bacteroidaceae,Lachnospiraceae,Veillonellaceae增加;Enterobacteriaceae减少) 和属水平 (Bacteroides,Clostridium XIVa,Parabacteroides增加;Prevotella,Ruminococcus减少) 上发现了微生物组组成的显著变化.

结论:

这一元分析证实了PSCI患者肠道微生物群组成的显著变化.
这些发现凸显了肠道微生物群在PSCI病理生理学中的潜在作用.

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