积极监测与低风险DCIS的治疗:LORD试验中的女性偏好
Renée S J M Schmitz1, Ellen G Engelhardt2, Miranda A Gerritsma3
1Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
European journal of cancer (Oxford, England : 1990)
|September 1, 2023
概括
大多数患有低风险管道癌 in situ (DCIS) 的女性更喜欢主动监测 (AS) 而不是传统治疗 (CT). 这凸显了需要确认AS的安全性,以缓解DCIS病例.
科学领域:
- 在瘤学瘤学.
- 乳腺癌研究研究 乳腺癌研究
- 临床试验 临床试验
背景情况:
- 在位管道癌 (DCIS) 可能是惰的,但往往经历了手术和放射治疗的过度治疗.
- 该LORD试验通过为患者提供选择来调查低风险DCIS的积极监测 (AS) 的安全性.
- 了解患者的偏好对于定制乳腺癌管理至关重要.
研究的目的:
- 在LORD试验中,描述AS和常规治疗 (CT) 臂之间的参与者分布.
- 确定患者选择AS或CT用于低风险DCIS的动机.
- 评估与患者在试验中的选择相关的因素.
主要方法:
- 在LORD试验中从基线问卷收集的数据.
- 对参与者分布和特征的描述性统计数据.
- 对患者报告的原因进行主题分析,并对相关因素进行多变量逻辑回归.
主要成果:
- 在377名女性中,76%选择AS,24%选择CT.
- 对AS的主要原因是:"治疗不必要" (59%) 和对AS的信任 (39%).
- 对CT的主要原因:担心癌症 (51%) 和感知到的确定性 (29%). 更低的教育程度和共享决策与AS偏好有关.
结论:
- 该LORD试验是第一个为低风险DCIS提供AS和CT之间的选择.
- 大多数女性更喜欢AS,表达对其安全性的信心.
- 患者的偏好强调了建立AS作为低风险DCIS的安全选择的重要性.
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