糖尿病视网膜病变和被诊断患有抑郁症之间的纵向双向关联:来自丹麦全国范围的基于登记册的队列研究的结果
Frederik N Pedersen1, Lonny Stokholm2, Nis Andersen3
1Department of Ophthalmology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Journal of diabetes and its complications
|September 1, 2023
概括
这项研究发现,在2型糖尿病患者中,糖尿病视网膜病变 (DR) 和抑郁症之间没有双向联系. 虽然DR与以前的抑郁病史较少相关,但抑郁症并不能预测未来DR的发展.
科学领域:
- 眼科医生 眼科 眼科
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 糖尿病视网膜病变 (DR) 是导致视力障碍的主要原因.
- 抗抑郁症和抑郁症之间的关系,特别是它的方向性,在大群体中仍然没有得到充分的研究.
- 了解这种关联对于管理2型糖尿病患者至关重要.
研究的目的:
- 为了调查糖尿病视网膜病变 (DR) 和诊断抑郁症之间的双向关联.
- 为了确定DR是否预测事件抑郁和抑郁是否预测事件DR在全国范围内队列.
主要方法:
- 一项基于国家登记的队列研究包括2型糖尿病患者接受糖尿病眼部查 (2013-2022年).
- 糖尿病视网膜病变的严重程度是从丹麦糖尿病视网膜病变登记处提取的.
- 诊断的抑郁症是使用来自丹麦国家患者登记册的医生诊断码来识别的.
主要成果:
- 在基线时患有DR的个体不太可能有被诊断的抑郁病史 (OR 0.77).
- 在多变量调整后,基线DR没有显著增加发生抑郁症的风险 (HR 1.02).
- 经过诊断的抑郁病史没有预测发生的DR (HR 0.89).
结论:
- 该研究没有发现证据支持DR与抑郁症之间的双向关联.
- 潜在的选择偏差,即抑郁症可能阻碍DR查出席率,可以解释基线观察到的反向关联.
- 需要进一步的研究才能充分阐明DR与心理健康之间的复杂相互作用.
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