用于确定和评估长寿干预措施的衰老生物标志物
Mahdi Moqri1, Chiara Herzog2, Jesse R Poganik3
1Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Genetics, School of Medicine, Stanford University, Stanford, CA, USA; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA.
Cell
|September 1, 2023
概括
开发可靠的衰老生物标志物对于评估长寿干预至关重要. 这项研究提出了一个标准化衰老生物标志物术语,表征和验证临床使用的框架.
科学领域:
- 老年学
- 生物标志物研究
- 临床试验
背景情况:
- 衰老生物学研究正在迅速扩大, 需要工具来评估人类的长寿干预措施.
- 生物标志物对于在实际时间范围内评估这些干预措施至关重要.
- 缺乏标准化的衰老生物标志物阻碍了它们的开发和临床验证.
研究的目的:
- 为老龄化生物标志物的术语和表征建立一个全面的框架.
- 为衰老生物标志物的分类和潜在的临床应用提供指导方针.
- 应对挑战并确定生物标志物验证的未来研究方向.
主要方法:
- 对老化生物标志物的现有文献进行审查和综合.
- 制定生物标志物定义和分类的建议框架.
- 对验证方法和临床实用性的讨论.
主要成果:
- 一个标准化衰老生物标志物术语和表征的框架.
- 老化生物标志物的分类与潜在的临床用例.
- 确定关键的验证步骤和正在进行的研究挑战.
结论:
- 标准化衰老生物标志物对于推进长寿研究和临床应用至关重要.
- 拟议的框架有助于开发和验证可靠的衰老生物标志物.
- 这项工作为在人类临床试验和实践中使用验证的生物标志物铺平了道路.
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