在机械通风的输管ICU患者中呼出的氧化 - - 一项可行性研究
Andreas Kofoed1, Mathias Hindborg1, Jeppe Hjembæk-Brandt1
1Department of Anesthesia and Intensive Care, Copenhagen University Hospital-North Zealand, Hilleroed, Denmark.
分数呼出的氧化 (FeNO) 可能有助于区分危急病患者的感染. 在感染或感染性休克的患者中观察到较低的FeNO水平,这表明FeNONO.
科学领域:
- 关键护理医学 关键护理医学
- 呼吸系统医学 呼吸系统医学
- 生物标志物 生物标志物
背景情况:
- 在重症患者中,区分炎症和感染是临床上具有挑战性的.
- 需要可靠的代孕标记物来识别感染.
- 氧化 (NO) 含量可以随着各种疾病而变化,使其成为潜在的标志物.
研究的目的:
- 为了研究在直管患者中测量部分呼出的氧化 (FeNO) 的可行性.
- 评估FeNO是否能区分感染者和非感染者,危急病患者.
- 探索FeNO作为重症监护室 (ICU) 设置中的潜在生物标志物.
主要方法:
- 观察性,前性,单中心可行性研究.
- 在ICU中包括20名被直管的患者.
- 使用化学发光分析仪测量内管中的FeNO.
主要成果:
- 在被直管的患者中,FeNO的测量成功且可靠.
- 与没有感染的患者相比,可疑感染的输管患者的FeNO中位数显著降低.
- 患有败血症的患者的FeNO中位数明显低于没有败血症的患者.
- 在肺炎患者中没有发现FeNO水平的显著差异.
结论:
- 在被直管的ICU患者中测量FeNO是可行的.
- 结果表明,受感染的输管患者的FeNO水平下降.
- 需要进行更大规模的试验来确认FeNO作为区分感染和炎症的生物标志物的实用性.
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