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精确调节异菌成年微生物组与人乳衍生的共生生物重新塑造肠道微生物组成和代谢物

Julie E Button¹, Casey M Cosetta¹, Abigail L Reens¹

¹Prolacta Bioscience, Duarte, CA 91010, USA.

Cell host & microbe

|September 1, 2023

概括

一种含有Bifidobacterium longum亚种infantis (B. infantis) 和人乳寡糖体 (HMO) 的新型共生菌在抗生素诱导的失生症后有效地恢复了健康志愿者的肠道微生物组平衡.

科学领域:

微生物学微生物学
胃肠病学胃肠病学
免疫学免疫学免疫学

背景情况:

活生物治疗产品具有临床应用的潜力,但在微生物组操纵方面面临挑战.
抗生素诱导的失生症是一种常见的临床情景,需要有效的恢复策略.

研究的目的:

评估一种由Bifidobacterium longum亚种infantis (B. infantis) 和人乳寡糖 (HMO) 组成的共生菌在恢复健康的肠道微生物群中的有效性.
研究由共生菌调解的微生物组恢复背后的机制.

主要方法:

在使用抗生素的56名健康志愿者中诱导肠道失调.
给出了B.infantis和HMOs的一种协生药物.
通过体外和体外研究评估微生物组合,代谢物概况和微生物相互作用.

主要成果:

在76%的受试者中,B. infantis以HMO-依赖的方式植入,达到相对较高的丰度.
植入导致了微生物组合和代谢物配置的改变,包括增加了Veillonella和更快的酸盐回收.
B. infantis和Veillonella共同培养表明乳酸转化为酸盐,这是一个关键的宿主影响代谢物.

结论:

测试的共生菌可重复性和可预测性地调节异生菌微生物组的恢复.
这种共生菌显示出临床应用的潜力,用于在失生症后恢复肠道健康.
这项研究强调了B. infantis和其他肠道微生物在介导宿主生理中的代谢相互作用.

关键词:

B. 婴儿科婴儿科这种细菌是Bifidobacterium.这是一个HMO.在 LBP LBP 中.维龙内拉 (Veillonella) 是一种的植物.肠道移植是一种肠道移植.我们的肠道微生物组.我们的肠道微生物群.人类牛奶中的寡糖类.活生生的生物治疗产品微生物组调制的微生物组调制酸 propionate 的使用方法

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