婴儿期严重支气管炎与6岁肺功能之间的关联
Geneva D Mehta1, Anna Chen Arroyo2, Zhaozhong Zhu3
1Brigham and Women's Hospital, Boston, MA, USA.
Respiratory medicine
|September 1, 2023
概括
严重的婴儿支气管炎与六岁时肺功能减弱有关. 这种早期的呼吸道疾病可能会增加晚年慢性肺病的风险.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统流行病学 呼吸系统流行病学
- 儿童呼吸系统健康 儿童呼吸系统健康
背景情况:
- 早期的呼吸道感染是一个重大的公共卫生问题.
- 识别肺功能下降的危险因素对于终身呼吸系统健康至关重要.
- 婴儿时期的严重支气管炎是长期肺部结果的潜在危险因素.
研究的目的:
- 调查婴儿时期严重 (住院) 支气管炎与6岁时肺功能之间的关联.
- 为了确定早期的呼吸道疾病是否会影响肺部发育.
- 为改善肺部健康的早期干预策略提供数据.
主要方法:
- 分析了两个前性队列研究:住院患有支气管炎的婴儿和健康的婴儿队列.
- 在6岁时进行螺旋测量的纵向随访.
- 多变量线性回归模型根据关键共变量 (例如社会经济地位,环境暴露,遗传学) 进行调整,以评估主要结果:预测FEV1% (pp) 和FEV1/FVCpp.
主要成果:
- 6岁时可获得425名有严重支气管炎病史的儿童和48名对照儿童的螺旋计数据.
- 与对照组相比,在经过调整后,患有严重支气管炎的儿童的FEV1pp (8%较低,p=0.004) 和FEV1/FVCpp (4%较低,p=0.007) 显著降低,即使在调整后.
- 两组之间没有观察到FVCpp或支气管扩展剂响应 (BDR) 的显著差异.
结论:
- 患有严重支气管炎住院的婴儿在6岁时显示FEV1和FEV1/FVC降低.
- 这些发现表明,在有严重婴儿支气管炎病史的儿童中,晚年患慢性呼吸道疾病的风险可能会增加.
- 对于患有严重支气管炎的婴儿,可能需要进行早期呼吸系统健康干预.
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