在更高的植物中,阿诺洛尔的酶选择性吸收和转移
Natalia S Podio1, Chengliang Sun2, Stacia Dudley2
1ICYTAC, CONICET and ISIDSA, Secretaría de Ciencia y Tecnología, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba X5000HUA, Argentina; Department of Environmental Science, University of California Riverside, CA 92521, United States.
The Science of the total environment
|September 1, 2023
概括
这项研究研究了β阻断剂阿提诺洛尔的不同形式 (反体) 如何在植物中被吸收和移动. 结果显示,植物可以优先吸收特定的阿诺洛尔反体,影响作物的制药命运.
科学领域:
- 环境化学环境化学
- 植物科学 植物科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 表面水中的药物通过农作物灌对人类的暴露带来风险.
- 关于植物吸收和影响,药品的性常常被忽视.
- 了解对抗选择性吸收对于评估农业中药物风险至关重要.
研究的目的:
- 为了评估植物中阿诺洛尔 (atenolol) 体的选择性吸收,生物度和转位.
- 为了研究植物对性药物暴露的反应,在反体水平上.
- 突出对陆地生态系统中新出现的污染物进行对抗体特异性分析的重要性.
主要方法:
- 培养Arabidopsis thaliana细胞和Lactuca sativa植物的水培养.
- 暴露于不同度的R/S-(±) -atenolol (1 mg/L,1 或 10 μg/L).
- 量化阿提诺洛尔反体和计算反体分数 (EF) 和转位因子 (TF).
主要成果:
- 阿拉比多普西斯塔利亚纳的细胞对R-(+) -阿提诺醇的摄取有适度的偏好 (EF = 0.532 ± 0.002).
- 乳草植物表现出对抗选择性吸收和转位,在10μg/L (EF = 0.42 ± 0.01) 时,S-(-) -atenolol的优先积累.
- 转位因子 (TF) 也表明了根和叶之间对抗选择性分布.
结论:
- 植物表现出奇拉制药阿特诺洛尔的对抗选择性吸收和转移.
- 药品在植物中的特异性行为对环境风险评估具有重要意义.
- 未来的研究应该考虑在陆地生态系统中制药命运和生态毒性的反体方面.
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