评估经常处理医疗器械的医院工作人员的塑化剂暴露:试点研究
Elisabeth Eckert1, Laura Kuhlmann2, Thomas Göen2
1Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Henkestr. 9-11, 91054, Erlangen, Germany; Bavarian Health and Food Safety Authority, Department of Risk Assessment, Eggenreuther Weg 43, 91058, Erlangen, Germany.
Environmental research
|September 1, 2023
概括
处理塑料医疗器械的医院工作人员表现出可测量的塑化剂的内部暴露. 血液银行技术人员的DEHP和DINCH代谢物含量较高,而 perfusionists则显示出更多的TEHTM,这表明工作场所特定的暴露.
科学领域:
- 职业健康 职业健康 职业健康
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 塑料医疗器械含有塑化剂,导致患者暴露.
- 有限的数据存在于医院工作人员对可塑剂的职业暴露.
研究的目的:
- 为了评估在医院工作人员处理塑料医疗器械的内部塑化剂暴露.
- 为了评估血液银行MTA和 perfusionists中DEHP,DINCH,DEHTP和TEHTM的尿中代谢物水平.
主要方法:
- 在一周的工作时间内采集换班前后的尿样.
- 精选塑化剂 (DEHP,DINCH,DEHTP,TEHTM) 的尿中代谢物的分析.
主要成果:
- 血液银行MTA显示尿中DEHP和DINCH代谢物水平明显升高.
- perfusionists 具有更高的 TEHTM 代谢物的检测频率.
- 工作场所的环境影响了个体的塑化剂代谢物水平.
结论:
- 定期处理塑料医疗器械有助于医院工作人员的内部塑化剂暴露.
- 通过吸入或皮肤接触暴露是可以证明的,但目前是边际的.
- 需要进一步的研究才能充分理解职业风险.
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