在Acyrthosiphon pisum中,Wnt通路调节了翅膀形态的确定
Ping Zhou1, Xin Zong1, Shuo Yan1
1Department of Plant Biosecurity and MARA Key Laboratory of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University, Beijing, 100193, China.
Insect biochemistry and molecular biology
|September 1, 2023
概括
虫中的翅膀二态是通过Wnt信号通路来调节的. 这一途径控制着后代是否发展翅膀或无翼的形式,适应环境变化.
科学领域:
- 发展生物学 发展生物学
- 昆虫生理学 昆虫生理学
- 遗传学 是一个遗传学.
背景情况:
- 翅膀二态是昆虫的一个关键生存策略,允许适应环境变化.
- 母虫向后代传递信号,影响它们成长为有翅膀或没有翅膀的成年人.
- 确切的机制决定了早期虫的翅膀形态在很大程度上是未知的.
研究的目的:
- 阐明早期虫中控制翅膀决定的分子机制.
- 确定参与调节虫翅膀发育的关键信号通路.
主要方法:
- 开发一种新的外科采样技术,用于精确地采集翅膀原始组织.
- 翼原始的转录组分析.
- 基因淘汰实验以抑制或激活特定的信号通路 (Wnt,miR-8).
- 在 nymphal 阶段观察翅膀发育和亡.
主要成果:
- 确定了Wnt信号通路作为在豆的早期第二阶段的翅膀决定的关键调节器.
- 抑制Wnt信号元件 (Wnt2,Wnt11b,fz2,vg,omb) 降低了有翅膀的虫的比例.
- 通过抑制miR-8激活Wnt信号,增加了翅膀虫的比例.
- 无翼的翅膀原始生物的亡与Wnt信号联系在一起,特别是在诱导翅膀的条件下通过fz2敲击激活.
结论:
- 虫翅膀的发育可塑性是由内在的Wnt路径调节的,以响应环境线索.
- Wnt途径在促进翅膀发育和诱导翅膀原生细胞的亡方面起着至关重要的作用,从而控制了翅膀二重形态.
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