大型抑郁症患者的心血管变化与双极性障碍患者的心血管变化
Fei Xie1, LinLin Zhou2, Qiang Hu3
1School of Public Health, Fudan University, Shanghai, China; Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, China.
Journal of affective disorders
|September 1, 2023
概括
心脏自主功能,特别是心率变化 (HRV),可能有助于区分单极性抑郁症 (UD) 和双极性抑郁症 (BD). 患有BD的患者表现出比UD患者更大的心脏不平衡,这表明HRV是潜在的生物标志物.
科学领域:
- 精神病学是一个精神病学.
- 心脏病学 心脏病学
- 生物标志物 生物标志物
背景情况:
- 从临床上讲,区分主要抑郁症 (MDD) 和双相情感障碍 (BD) 是一个很大的挑战.
- 可靠的生物标志物对于准确的诊断至关重要.
- 作为潜在的诊断指标,正在探索心脏自主功能.
研究的目的:
- 评估心脏自主功能是否能够区分单极性抑郁 (UD),双极性抑郁 (BD) 和双极性躁狂 (BM).
- 为了确定差异诊断的潜在心理生理学生物标志物.
主要方法:
- 招募了791名患有情绪障碍的患者 (191名UD,286名BD,314名BM),至少两周不服用药物.
- 使用心率变化 (HRV) 和脉冲波速度 (PWV) 通过手指光电脉镜测量心血管状况.
- 分析数据调整年龄,性别和体重指数.
主要成果:
- 患有BD的患者表现出较低的HRV和比UD和BM组更高的心率.
- 与BD组相比,UD组的PWV指标较低.
- 在对共变量进行调整后,HRV和PWV的变化仍然显著,高频HRV指数显示出最大的效应大小和最高的AUC (0.714).
结论:
- 双极性抑郁症 (BD) 与单极性抑郁症 (UD) 相比,与更大的心脏失衡有关.
- 心率变化 (HRV) 显示出作为区分UD和BD的心理生理学生物标志物的潜力.
- 需要进一步的研究来证实这些发现.
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