在1型糖尿病中,酒精消费与身体脂肪分布之间的关联
Ina Lampenius1, Valma Harjutsalo1, Erika B Parente1
1Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Diabetes research and clinical practice
|September 1, 2023
概括
饮酒与1型糖尿病 (T1D) 患者内脏脂肪增加有关. 更高的摄入量与更多的内脏脂肪相关,高风险饮酒会增加中心肥胖风险.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 1型糖尿病 (T1D) 的管理需要仔细考虑生活方式因素.
- 身体脂肪分布是代谢健康和心血管风险的关键指标.
研究的目的:
- 调查T1D成年人的酒精消费模式和身体脂肪分布之间的关系.
- 为了确定这种人群中,酒精摄入是否与中心肥胖 (CO) 和一般肥胖 (GO) 有关.
主要方法:
- 利用双能X射线吸收仪 (DXA) 来评估548名T1D成年人的身体组成.
- 根据已确定的内脏脂肪质量 (VFM) 和身体脂肪质量 (BFM) 的百分比来定义中央和一般肥胖症.
- 使用问卷数据将酒精消费分为禁酒者,低风险,中等风险和高风险群体.
主要成果:
- 在两种性别中,较高的酒精消费和增加的VFM%之间观察到线性关联 (r2=0.23).
- 增加的酒精摄入量与男性的BFM%较高有关,但与女性无关.
- 饮酒量每周增加的剂量,将中心肥胖的几率提高3% (或1.03).
- 高风险的酒精消费显著增加了中央 (OR 7.3) 和一般肥胖 (OR 5.3) 的几率.
结论:
- 酒精消费与T1D成年人的内脏脂肪量线性相关,不论性别.
- 酒精摄入量与整体体脂质之间的关联取决于性别.
- 高风险的酒精消费在T1D患者中对中心和一般肥胖造成重大风险.
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