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对细胞抵抗基因毒性压力的比较转录基因研究进行系统审查

Z B Ismailov1, E S Belykh1, A A Chernykh2

  • 1Institute of Biology of Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, 28b Kommunisticheskaya St., Syktyvkar 167982, Russia.

Mutation research. Reviews in mutation research
|September 1, 2023
PubMed
概括

瘤细胞对癌症治疗产生抵抗力,但对基因表达变化的研究显示出很少的一致性. 过度表达的ABCB1和IFITM1以及下调的BNIP3是常见的发现,表明复杂的抵抗机制.

关键词:
不同表达的基因.外体沟通是外体沟通.基因毒性压力是什么?转录组 转录组 是一个转录组.瘤的抗药性 瘤的抗药性

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In vitro Mutagenesis01:16

In vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.