肝移植后慢性病 肝移植后慢性病
Franco H Cabeza Rivera1, Beatrice P Concepcion2, Swee-Ling L Levea3
1Katz Family Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, FL.
Advances in kidney disease and health
|September 1, 2023
概括
肝移植后慢性病 (CKD) 很常见,增加死亡风险. 管理氨酸抑制剂和并发症等危险因素可以减缓CKD的进展.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肝病学 肝病学是一种肝病学.
- 移植医学 移植医学
背景情况:
- 慢性病 (CKD) 是肝移植接受者的常见并发症.
- 在这一群体中,CKD与较高的死亡风险有关.
- 确定的风险因素包括术前问题,捐赠因素和与接受者相关的条件.
研究的目的:
- 审查肝移植患者中CKD的风险因素,进展和管理.
- 为突出预防和治疗移植后功能障碍的策略.
主要方法:
- 对肝移植接受者中CKD发展的已确定的风险因素的审查.
- 对CKD进展模式的分析.
- 讨论适用于肝移植患者的管理策略.
主要成果:
- 慢性病的发展受到外科手术期间的因素 (例如,急性损伤),捐赠因素 (例如,扩展标准移植) 和接受因素 (例如,氨酸抑制剂,代谢综合征,糖尿病,肥胖) 的影响.
- 慢性瘤呈现双模性进展:最初的快速阶段和随后的逐渐下降.
- 管理包括解决并发病症,并可能最大限度地减少氨酸抑制剂的使用.
结论:
- 标准的CKD管理策略适用于肝移植接受者.
- 最小化氨酸抑制剂可以减缓功能障碍的进展.
- 移植为晚期CKD患者提供了生存益处,美国有专门的分配政策,用于早期移植后的发育.
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