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Updated: Jul 17, 2025

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通过依赖于IDR的液态-液态相分离,LEF1增强了β-catenin的交换活性

Bing Zhao1, Zhuoxin Li1, Shaoqing Yu2

  • 1National Center of Biomedical Analysis, Beijing, China.

Life science alliance
|September 1, 2023
PubMed
概括

在癌症中,LEF1与β-catenin形成液态凝结物,这对于Wnt/β-catenin信号传递至关重要. 破坏这种本质上有障碍的区域 (IDR) 会阻止瘤的生长,从而提供新的治疗点.

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