金属- sideromycin作为一个双重功能复合物,用于打击抗微生物耐药性
Chenyuan Wang1, Yushan Xia1, Runming Wang1
1Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, PR China.
Nature communications
|September 1, 2023
概括
将 cefiderocol与合物木酸盐 (CBS) 结合,显示出强大的协同作用,可以对抗抗性格兰氏阴性细菌. 这种新的联合疗法增强了疗效,打击了耐药性,并在小鼠肺炎模型中改善了生存率.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 药物发现 药物发现 药物发现
背景情况:
- 抗菌素耐药性 (AMR) 是一个日益增长的全球健康威胁.
- 塞菲德罗科尔是一种 sideromycin 抗生素,用于对抗阴性细菌,但耐药性正在出现.
- 需要新的策略来对抗耐药性感染.
研究的目的:
- 为了研究 cefiderocol 与金属药物结合的协同效应.
- 评估这种联合治疗对抗耐药格兰氏阴性病原体的潜力.
- 探索观察到的协同活动背后的机制.
主要方法:
- 在实验室中测试了对Pseudomonas aeruginosa和Burkholderia cepacia的 cefiderocol和合 bismuth 酸盐 (CBS) 协同作用.
- 对CBS对抗生物膜和抗药性发展的赛菲德罗科尔疗效的影响评估.
- 在小鼠急性肺炎模型中的体内评估.
- 关于对Cefiderocol吸收的金属离子竞争的研究.
主要成果:
- 在Cefiderocol和CBS之间观察到强烈的协同抗菌活性.
- CBS增强了对生物膜和重新敏感的耐药菌株的赛菲德罗科尔疗效.
- 同时治疗显著增加了小鼠的生存率,并减少了小鼠的细菌肺负荷.
- 有证据表明,高 bismuth 离子与铁竞争,以结合 cefiderocol,从而增强吸收.
结论:
- 金属- sideromycin 组合,特别是 cefiderocol 与CBS,提供了一个有前途的策略来对抗耐药的阴性细菌.
- 这种组合疗法证明了增强的疗效,克服了耐药性,并在体内表现出治疗潜力.
- 了解金属药物相互作用机制为开发下一代抗菌剂提供了洞察力.
更多相关视频
12:03Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
Published on: April 18, 2019
26.3K
09:09High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity
Published on: November 16, 2016
7.9K
相关概念视频
01:27Combined Effects of Drugs: Synergism
4.0K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
4.0K
01:30Development of Antibiotic Resistance
38
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
38
02:56Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K