激光接SEBS/PP混合聚合物的保质期,生物负担,水和氧透性研究
Satisvar Sundera Murthe1, Srimala Sreekantan2,3, Rabiatul Basria S M N Mydin4
1School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Engineering Campus, 14300, Nibong Tebal, Penang, Malaysia.
Scientific reports
|September 1, 2023
概括
一个新的SEBS/PP血囊原型为传统的PVC-DEHP血囊提供了更安全的替代方案. 这种材料表现出优越的氧气透性和较低的水透性,确保更好的红细胞呼吸和防止脱水. 它还显示了减少生物负担,最大限度地降低了患者的风险.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 聚合物科学 聚合物科学
背景情况:
- 聚乙烯 (PVC) 血袋通常使用二甲乙烯 (DEHP) 甲酸盐 (DEHP) 以提高灵活性.
- DEHP可以从PVC中入储存的血液中,对患者构成潜在的健康风险.
- 需要更安全的替代材料来制造血液袋.
研究的目的:
- 开发和评估使用SEBS/PP混合物的新型血液袋原型.
- 为了比较SEBS/PP原型与传统的PVC-DEHP血囊的性能特征.
- 评估SEBS/PP适用于血液储存的适用性,重点关注透性,保质期和生物负担.
主要方法:
- 使用吹塑制造SEBS/PP血囊原型的制造.
- 使用优化的CO2激光参数 (60%功率,70英寸/秒速度,500PPI) 接SEBS/PP层.
- 性能测试包括水透性,氧透性,保质期和生物负担分析.
主要成果:
- 在40天后,与PVC-DEHP (662.7cc/m2/24h) 相比,SEBS/PP的氧气透性显著提高 (1486.6cc/m2/24h),支持红细胞呼吸.
- SEBS/PP的水透度比PVC-DEHP (0.221 g/h·m2) 低 (0.098 g/h·m2),表明其具有优越的防水性能.
- 两种材料在40天后都没有显示视觉退化;SEBS/PP具有较低的生物负担 (115 CFU与213 CFU).
结论:
- 这种SEBS/PP血囊原型是PVC-DEHP血囊的有希望的替代品.
- 其增强的透性特性和降低的生物负担提供了潜在的安全益处,特别是对于高风险患者.
- 需要进一步的临床评估来确认其在输血应用中的有效性.
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