确定益生菌信号通路与COVID-19疫苗诱导的月经变化之间的因果关系
Rima Hajjo1,2,3, Ensaf Momani4,5, Dima A Sabbah6
1Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, P.O. Box 130, Amman, 11733, Jordan. r.hajjo@zuj.edu.jo.
NPJ vaccines
|September 1, 2023
概括
用BNT162b2接种COVID-19疫苗可能会导致短期的月经周期不规则. 信息学分析确定了关键的基因驱动因素,但研究结果表明不会对生育产生长期影响.
科学领域:
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
- 计算生物学 计算生物学
背景情况:
- 包括mRNA BNT162b2在内的COVID-19疫苗对于减少疾病严重程度和死亡率至关重要.
- 在接种疫苗后报告的月经周期不规则引起了人们对生育能力的担忧.
- 了解疫苗引起的副作用背后的生物机制至关重要.
研究的目的:
- 在接种BNT162b2疫苗后,调查月经周期不规则的因果驱动因素.
- 利用生物信息学和网络生物学来探索疫苗与不良事件的关系.
- 评估对生育能力的潜在长期影响.
主要方法:
- 疫苗接种后的基因表达分析.
- 网络生物学分析以确定因果关系.
- 确定涉及月经不规则的关键转录因子和生物标志物.
主要成果:
- 确定了五种高度信任的转录因子 (IRF1,STAT1,RelA,STAT2,IRF3) 作为因果驱动因素.
- 包括TNF,IL6R和IL6ST在内的生物标志物与月经不规则有关.
- 网络分析表明,BNT162b2效应模仿了益生素信号传递,但是暂时的.
结论:
- 与BNT162b2相关的月经不规则可能是短暂的.
- 鉴定的机制并不表明长期不育的风险.
- 信息学方法可以用于研究其他疫苗或药物的副作用.
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