乳腺癌免疫疗法:一个全面的审查
Samaneh Keshavarz1, Jack R Wall2, Somayeh Keshavarz1
1School of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran.
Clinical and experimental medicine
|September 1, 2023
概括
收养细胞疗法 (ACT) 提供了先进的癌症治疗选择. 这篇评论探讨了新的方法,如化学抗原受体 (CAR) NK细胞和乳腺癌免疫治疗的阿普坦技术.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物技术是生物技术.
背景情况:
- 癌症仍然是一个重大的全球健康挑战,尽管治疗方面取得了进展.
- 采用细胞疗法 (ACT) 是一种利用免疫细胞的有前途的癌症治疗方式.
- 现有的ACT方法面临着像移植拒绝这样的挑战,需要创新的解决方案.
研究的目的:
- 提供乳腺癌 (BC) 治疗的全面概述,从传统方法到先进的基于细胞的策略.
- 突出新型免疫疗法技术,重点关注仿真抗原受体 (CAR) NK细胞和BC的aptamer技术.
- 评估自然杀手 (NK) 细胞作为基于CAR的疗法中更安全的替代品的潜力.
主要方法:
- 对癌症治疗中采用细胞疗法 (ACT) 的当前文献的综述.
- 基因工程技术的分析,包括仿真抗原受体 (CAR) 技术.
- 探索阿普坦技术及其在癌症免疫治疗中的作用.
主要成果:
- 化学抗原受体 (CAR) T细胞疗法是FDA批准用于某些血液癌症.
- 自然杀手 (NK) 细胞正在成为基于CAR的疗法更安全的候选人,可能克服排斥问题.
- 阿普塔默 (Aptamer) 技术在增强BC免疫疗法方面显著有前途.
结论:
- ACT,特别是与像CAR NK细胞这样的工程免疫细胞,代表了癌症治疗的重大进步.
- 像CAR和aptamers这样的新技术为有效的乳腺癌免疫治疗提供了新的途径.
- 对最小化ACT并发症和探索NK细胞等新细胞类型的持续研究对于未来的治疗成功至关重要.
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