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模拟免疫细胞转化在瘤免疫微环境中的作用

Alexander S Moffett^1,2, Youyuan Deng^3,4, Herbert Levine^5,6,7

¹Center for Theoretical Biological Physics, Northeastern University, Boston, MA, 02115, USA.

Bulletin of mathematical biology

|September 1, 2023

概括

瘤细胞可以转换免疫细胞,将它们从抗瘤角色转移到亲瘤角色. 在瘤微环境 (TIME) 中这种免疫细胞转化可以导致免疫系统和癌症之间的局.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
数学生物学数学生物学

背景情况:

瘤存在于一个复杂的瘤微环境 (TME) 中.
瘤免疫微环境 (TIME) 涉及瘤和免疫细胞之间的相互相互作用.
生态概念被用来描述TIME动态,但瘤对免疫细胞的转化还未得到充分研究.

研究的目的:

开发一个最小的生态模型的时间,包括免疫细胞转化.
探索免疫细胞转换对时间动态的影响.
突出免疫细胞转化在癌症建模中的重要性.

主要方法:

开发一个最小的生态模型,专注于在时间内对免疫细胞的转化.
分析模型参数,以了解免疫转换对系统动态的影响.
在不同条件下模拟瘤-免疫细胞相互作用.

主要成果:

免疫细胞转化显著改变了瘤免疫微环境的动态.
该模型表明,免疫转换扩大了免疫-瘤共存的参数范围.
一个局阶段,免疫系统和瘤达到平衡,更有可能与免疫转换.

结论:

免疫细胞转化是影响瘤与免疫相互作用的关键因素.
了解免疫转换对于准确建模时间至关重要.
需要进一步研究详细的数据驱动模型,才能充分理解免疫转换在癌症中的后果.

关键词:

一般化的洛特卡-沃尔特拉方程免疫细胞转化转化免疫瘤的微环境

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