在UPSIDE队列中,Per-和多醇基物质,妊娠体重增加,产后体重保持和身体成分
Carolyn W Kinkade1, Zorimar Rivera-Núñez2,3, Sally W Thurston4,5
1Environmental and Occupational Sciences Institute, Rutgers University, Piscataway, 170 Frelinghuysen Road, Piscataway, NJ, 08854, USA. Caw136@scarletmail.rutgers.edu.
Environmental health : a global access science source
|September 1, 2023
概括
怀孕期间暴露于per-和多醇基物质 (PFAS),特别是PFOA和PFHxS,与较低的妊娠体重增加和产后体重保持有关. 这些发现表明对母亲和婴儿健康结果的潜在影响.
科学领域:
- 环境健康科学 环境健康科学
- 生殖健康 生殖健康
- 毒理学 毒理学 毒理学
背景情况:
- 和多醇基物质 (PFAS) 是广泛存在的合成化学物质,已知与内分泌干扰和改变体重增加有关.
- 目前关于PFAS对妊娠期体重增加 (GWG) 和产后体重指数 (BMI) 的影响的研究有限且不一致.
- 了解这些关联至关重要,因为GWG和产后BMI是孕产妇和婴儿健康的关键预测因素.
研究的目的:
- 调查第二个三个月的血清PFAS水平与妊娠体重增加 (GWG) 和产后体重保持 (PPWR) 之间的关系.
- 为了检查特定的PFAS (PFOS,PFOA,PFNA,PFHxS,PFDA) 与孕产妇肥胖症之间的关联.
- 根据怀孕前的BMI,探索这些关联中的潜在差异.
主要方法:
- 这项研究分析了243名参与"理解怀孕信号和婴儿发育" (UPSIDE/UPSIDE-MOMs) 研究的数据.
- 使用多变量线性回归模型来评估日志转换的PFAS水平与GWG,PPWR和身体脂肪百分比之间的关系.
- 使用权重定量和回归来评估五个关键的PFAS对母体测量结果的综合影响.
主要成果:
- perfluorooctanoic 酸 (PFOA) 和 perfluorohexanesulfonic 酸 (PFHxS) 与分娩后6个月和12个月的总GWG和PPWR相反相关.
- PFOA暴露也与6个月和12个月的较低体脂百分比有关,特别是在怀孕前BMI较高的参与者中.
- 联合PFAS混合物显示,在整个队列中,与12个月的产后体重保持有反向关联.
结论:
- 怀孕期间接触PFAS,特别是PFOA和PFHxS,与改变的妊娠期体重增加和产后肥胖症有关.
- 这些发现突出了对胎儿发育和长期母亲心脏代谢健康的潜在风险.
- 需要进一步的研究,以了解 PFAS 在怀孕期间暴露的全部影响.
关键词:
肥胖症是一种脂肪.体重指数 (Body Mass Index) 是一个指数.内分泌干扰 干扰内分泌系统怀孕期间体重增加.和多醇基物质是多和多醇基物质.产后体重保持 产后体重保持怀孕 怀孕 怀孕 怀孕更多相关视频
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