多不和脂肪酸与喘的关联:一个横截面研究
Gangtie Liu1, Hengbo Ye2, Qian Cheng2
1Department of Pediatrics, Taian Maternal and Child Healthcare Hospital, No.386 Longtan Road, Taian, 271000, Shandong Province, People's Republic of China. tafyenk@outlook.com.
摄入更多的多不和脂肪酸 (PUFA),特别是多可沙赫酸,与降低儿童喘风险有关. 这种保护作用在怀孕期间暴露于母亲吸烟的男性和儿童中更为明显.
科学领域:
- 营养流行病学 营养流行病学
- 儿科呼吸系统健康 儿科呼吸系统健康
- 欧米茄-3脂肪酸 研究研究
背景情况:
- 喘是儿童的重大全球健康问题.
- 饮食因素,包括多不和脂肪酸 (PUFA),正在越来越多地研究它们在喘发展中的作用.
- 了解PUFA与喘的联系可以为预防策略提供信息.
研究的目的:
- 调查各种PUFA的饮食摄入量与儿童喘患病率之间的关联.
- 探索性别,年龄和母亲吸烟对这种关系的潜在改变影响.
主要方法:
- 利用了来自美国国家健康和营养检查调查 (NHANES) (1999-2018) 的14727名参与者的数据.
- 使用描述性分析和加权多变量逻辑回归来评估PUFA摄入量和喘相关性.
- 根据性别,年龄和母亲吸烟史进行了分组分析.
主要成果:
- 总共有15.38%的参与者患有喘.
- 饮食中摄入的多可萨赫萨酸 (DHA),总n-3PUFA和eicosapentaenoic acid (EPA) 显示与儿童喘有负面关联.
- 亚组分析显示,在男性,5-12岁儿童和那些母亲在怀孕期间吸烟的儿童中,DHA摄入量和喘之间存在更强的负相关性.
结论:
- 饮食中摄入的DHA与儿童喘风险降低显著相关.
- DHA对儿童喘的保护作用在特定的亚组中尤为明显,包括男性,5-12岁的儿童,以及那些在怀孕期间有母亲吸烟史的儿童.
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