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用于诊断和治疗NET的放射性药物

Maria Papachristou¹

¹Department of Nuclear Medicine - PET/CT, Greece. papacmaria@yahoo.gr.

Hellenic journal of nuclear medicine

|September 2, 2023

概括

核医学在神经内分泌瘤 (NETs) 的治疗中推进了体静止素受体成像和受体放射性核酸治疗 (PRRT). 新的放射性药物提供了改进的可视化和有针对性的治疗,以最小的副作用提高患者的治疗结果.

科学领域:

核医学是一种核医学.
放射性药物开发的发展.
在瘤学瘤学.

背景情况:

索马托斯坦素受体成像已经从放射性演变为印-111和-99m标记的类似物.
定子发射断层扫描 (PET) 图像利用标记为-68和铜-64的体静止素类似物,提高瘤检测灵敏度.
放射性药物如18F-DOPA和11C-5-HTP在可视化胃肠道胰腺神经内分泌瘤 (GEP-NETs) 方面表现有前途.

研究的目的:

审查对神经内分泌瘤 (NETs) 索马托斯坦素受体成像和受体放射性核素治疗 (PRRT) 的进展.
讨论用于NET诊断和治疗的放射性药物的演变.
探索新兴疗法,如针对转移性NET的向性α粒子疗法 (TAT).

主要方法:

对图像成像 (SPECT和PET) 的历史和当前放射标记的体静止素类似物进行审查.
使用各种同位素 (In-111,Y-90,Lu-177) 的受体放射性核酸治疗 (PRRT) 的分析.
对转移性NET的向性α粒子治疗 (TAT) 剂 (Ac-225,Bi-213) 的评估.

主要成果:

使用索马托他类型的SPECT和PET成像显示了瘤检测的提高灵敏度.
用Y-90和Lu-177标记类型的PRRT在转移性NET中显示出客观反应和长期的疾病控制.
像Ac-225-DOTATATE这样的TAT药物表现出部分反应,毒性最小,需要进一步调查.

结论:

核医学对NET成像和治疗至关重要,目前正在进行的研究重点是更高 afinity somatostatin类似物.
对于不可操作或转移的NET,PRRT提供了一个有前途的治疗选择,具有已确定的疗效和可管理的副作用.
向的α粒子疗法代表了NET治疗的新方法,需要进一步的随机对照试验.

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