乳腺癌治疗的最新进展
1Interbalkan Medical Center, Thessaloniki, Greece. sophia.levva@gmail.com.
Hellenic journal of nuclear medicine
|September 2, 2023
概括
基因组面板正在彻底改变乳腺癌的治疗方法,特别是对光线亚型的治疗. 超低风险标志表明出色的预后,允许缓解治疗计划,避免不必要的化疗.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 个性化医疗是个性化的医疗.
背景情况:
- 乳腺癌治疗决策取决于分子亚型.
- 辅助系统治疗对三阴性和HER2阳性乳腺癌的好处很明显.
- 确定在发光性乳腺癌中需要辅助化疗的需求以前是具有挑战性的,导致过度治疗或治疗不足.
研究的目的:
- 突出基因组小组在定义光线乳腺癌预后方面的重要性.
- 讨论基因表达试验在指导辅助系统治疗决策中的作用.
- 引入超低风险签名的概念及其对治疗降级的影响.
主要方法:
- 使用基因组面板和基因表达试验 (例如,Oncotype,Mammaprint) 来评估复发风险.
- 基于分子亚型和基因组风险特征分析患者数据.
- 评估不同风险类别的预后意义,包括超低风险特征.
主要成果:
- 基因组面板对于光线乳腺癌的预后越来越重要,与解剖范围竞争.
- 马马普林特检测发现了一种与优秀预后相关的超低风险特征.
- 患有超低风险特征的患者,无论年龄,临床风险或接受的治疗,乳腺癌8年特定存活率 (BCSS) 超过99%.
- 在超低风险组中,远程转移是罕见的.
结论:
- 基因组风险分层对照性乳腺癌的个性化治疗至关重要.
- 通过Mammaprint识别的超低风险特征允许显著的治疗降级.
- 这一发现使医生能够避免过度治疗,并为光线乳腺癌患者的一个子集提供了有利的前景.
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