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使用人性化小鼠,SIV黑猩猩向HIV-1的病毒进化

James Z Curlin1,2, Kimberly Schmitt1, Leila Remling-Mulder1

  • 1Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.

Journal of medical primatology
|September 2, 2023
PubMed
概括

人类免疫缺陷病毒1型 (HIV-1) 是从人类的猿类免疫缺陷病毒 (SIVcpz) 进化而来的. 人性化小鼠模型通过分析病毒载量,CD4+T细胞损失和序列通道期间的遗传突变,有效地追踪HIV-1适应.

关键词:
艾滋病病毒-1 艾滋病病毒-1这就是SIVcpzMB897的原因.在hu-HSC小鼠中.连续传递通过.病毒演化的病毒演化.

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