JARID2与NuRD复合体协调,通过对脂肪细胞衍生性勒素的反应促进乳腺瘤发生
Wei Liu1,2, Yi Zeng1,3, Xinhui Hao1
1Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, P. R. China.
Cancer communications (London, England)
|September 2, 2023
概括
朱蒙吉和含有AT丰富的相互作用域2 (JARID2) 通过调节新陈代谢和细胞功能来促进乳腺癌的生长和进展. 准JARID2为乳腺癌提供了潜在的治疗策略,即使是在肥胖的背景下.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 具有Jumonji C (JmjC) 域的蛋白质与癌症进展有关.
- 在乳腺癌中Jumonji和含有2 (JARID2) 的富含AT相互作用域的特定作用尚不清楚.
- 研究JARID2在乳腺癌中的功能及其与肥胖的联系至关重要.
研究的目的:
- 阐明JARID2在乳腺癌发育和进展中的作用.
- 为了探索JARID2,肥胖和乳腺癌之间的联系.
- 确定JARID2影响乳腺癌细胞的分子机制.
主要方法:
- 利用免疫组织化学和公共数据库 (TCGA,GEO) 来评估JARID2表达.
- 进行了体外测试 (增殖,侵袭,茎状) 和体内异种移植模型.
- 采用RNA测序,ChIP测序和共免疫沉来识别分子通路和相互作用.
主要成果:
- 在乳腺癌中JARID2的表达很高,促进细胞增殖,入侵和干细胞.
- JARID2与NuRD复合体相互作用,抑制像BRCA2,RB1和INPP4B这样的瘤抑制基因.
- JARID2表达通过JAK2 / STAT3通路由瘦素调节,将肥胖与乳腺癌进展联系起来.
结论:
- JARID2显著驱动乳腺瘤的发生和进展.
- JARID2与NuRD复合体的相互作用和勒的调节突出了其多方面的作用.
- 在乳腺癌治疗中,JARID2 是一个有前途的治疗标.
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