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Updated: Jul 17, 2025

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泰莫索洛米德对瘤突变负担和黑色素瘤细胞微卫星不稳定性的影响

Masahide Sawada1, Tokimasa Hida1, Takafumi Kamiya1

  • 1Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.

The Journal of dermatology
|September 2, 2023
PubMed
概括

泰莫佐洛米德 (TMZ) 增加了黑色素瘤细胞中的瘤突变负担 (TMB),可能提高免疫治疗的有效性. 然而,TMZ并没有在这些细胞中诱导微卫星不稳定性 (MSI).

关键词:
外基因组测序是指外基因组的测序.免疫检查点抑制剂 免疫检查点抑制剂黑色素瘤是一种黑色素瘤.微卫星的不稳定性泰莫索洛米德 (temozolomide) 是一种有毒的物质.

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