癌症导向手术对转移性头癌的生存益处
Runqiu Zhu1,2, Huiyong Zhu1
1Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
The Laryngoscope
|September 2, 2023
概括
针对癌症的手术 (CDS) 显著改善了转移性头癌 (M1 HNC) 患者的生存率. 年轻的患者,早期疾病患者或接受放射治疗的患者特别受益于这种治疗.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 头部和部癌症研究研究
背景情况:
- 转移性头癌 (M1 HNC) 是一个重大的临床挑战.
- 癌症导向手术 (CDS) 在改善M1 HNC的存活率方面的作用仍然是积极研究的领域.
研究的目的:
- 评估CDS对M1 HNC患者的生存益处.
- 确定从CDS中获得最大益处的特定患者子组.
主要方法:
- 对M1 HNC.患者的SEER数据库的回顾性分析.
- 倾向分数匹配 (PSM) 以尽量减少CDS和非CDS组之间的偏差.
- 卡普兰-梅尔分析,日志级别测试和考克斯比例危险模型,以评估总生存率 (OS) 和癌症特异性生存率 (CSS).
主要成果:
- 在匹配的队列中,CDS与显著更高的中位数OS (19.0 vs. 9.0个月) 和CSS (21.0 vs. 9.0个月) 相关.
- 多变量分析证实CDS是OS和CSS的有利预后因素.
- 亚组分析表明,年轻患者,已婚患者,I-II级瘤,口腔大部部位,早期T/N阶段以及接受放射治疗的患者都有好处. 接受化疗的患者没有显示生存益处.
结论:
- 癌症导向手术 (CDS) 为被诊断为转移性头癌 (M1 HNC) 的患者提供了生存优势.
- 某些患者亚群,以年轻年龄,特定瘤特征和并发放射治疗为特征,更有可能从CDS中受益.
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