饮食中的核酸可以防止快速生长的野生脊椎动物中葡萄糖皮质激素诱导的端粒磨损
Stefania Casagrande1, Jasmine L Loveland2, Marlene Oefele1
1Max Planck Institute for Biological Intelligence, Evolutionary Physiology Group, Seewiesen, Germany.
Molecular ecology
|September 2, 2023
概括
核酸的可用性对于预防面临压力的发育动物的端粒侵蚀至关重要. 补充核酸支持细胞能量生产和端粒维护,这对长期健康至关重要.
科学领域:
- * 细胞和分子生物学
- *生态学和进化生物学
- *生理学和内分泌学
背景情况:
- * 染色体上的保护帽子 - - 端粒因细胞复制和压力而缩短,影响成年人的健康和寿命.
- *代谢端粒磨损假设 (MeTA) 假设端粒动力学受到生物体的能量状态的影响,由激素和营养素发出信号.
- * 葡萄糖皮质类药物促进了代谢,可能会损害端粒维护,而核酸类药物则通过拉巴胺素 (TOR) 途径的标激活了 anabolic 途径,可能会防止消耗.
研究的目的:
- * 调查核酸和葡萄糖皮质在压力下快速发育期间调节端粒动态中的作用.
- * 在自然环境中测试代谢端粒磨损假说 (MeTA).
- * 为了检查基底的分子机制端粒维护,以响应能量信号.
主要方法:
- *与对照人群相比,用葡萄皮质醇,核酸或两者一起对幼大的巨乳 (Parus major) 进行实验性操纵.
- *测量端粒长度的变化.
- *分析与TOR激活,线粒体功能,端粒维护和抗氧化剂防御相关的基因表达.
主要成果:
- * 葡萄糖皮质激素治疗导致端粒磨损,而核酸补充剂阻止了这一点.
- * 结合核酸和葡萄糖皮质激素治疗 (NucCort-chicks) 显示TOR激活增加,线粒体ATP产生增强,端粒维护和抗氧化基因的表达增加.
- *NucCort小表现出更高的有氧ATP生产效率.
结论:
- *核酸的可用性是防止快速生长过程中的端粒侵蚀的关键因素,尤其是在压力条件下.
- *这些发现支持MeTA,表明代谢信号 (核酸) 可以抵消压力激素 (葡萄皮质激素) 对端粒维护的负面影响.
- * 充足的核酸供应促进了细胞能量状态,并提高了对端粒保护和抗氧化剂防御的关键基因的调节.
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