开发一种现代化方法的原型,以评估作物保护化学安全性
Richard A Currie1, John Abbott2, David A Dreier2
1Syngenta Ltd, Bracknell, UK.
ALTEX
|September 2, 2023
概括
美国环保署的目标是到2035年逐步停止对脊椎动物的测试. 本研究提出了一种新的作物保护化学品风险评估方法,避免对脊椎动物进行测试,同时确保可靠的人类健康和环境保护.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 监管科学 监管科学
背景情况:
- 美国环保署的指令要求在2035年之前停止对脊椎动物进行测试.
- 目前对农作物保护化学品的风险评估策略很长,并依赖于脊椎动物的测试.
- 需要现代化,科学合理的方法来满足监管要求.
研究的目的:
- 开发和演示一种作物保护化学品风险评估战略,而不用对脊椎动物进行测试.
- 与传统方法相比,确保对风险评估的同等信心.
- 为了满足机构的监管需求,同时保持高质量的评估.
主要方法:
- 与监管科学家讨论问题制定,以定义挑战.
- 开发一个概念模型,用于新的方法.
- 与传统测试包并行提交和评估新的方法.
- 对缺陷的分析,以指导代改进.
主要成果:
- 已经开发出一种新的风险评估方法的概念模型.
- 并行评估将确定新方法的有效性.
- 缺陷分析将为未来的工具和方法开发提供信息.
结论:
- 拟议的战略旨在提供可靠的风险评估,而不需要化学特异性脊椎动物试验.
- 成功实施可以成为利益相关者参与和接受新监管范式的基础.
- 该倡议支持在化学风险评估中转向替代方法.
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