糖尿病和糖尿病前期患者的睡眠结构改变:来自Baependi心脏研究的发现
Daniel M Chen1, Tâmara P Taporoski1, Shaina J Alexandria1
1Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Sleep
|September 2, 2023
概括
糖尿病和糖尿病前期与REM睡眠的减少有关,即使没有中度至重度的睡眠呼吸暂停. 糖尿病患者也经历了更深的睡眠 (N3),这表明睡眠结构发生了变化.
科学领域:
- 睡眠医学 睡眠医学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 睡眠呼吸障碍 (SDB) 在糖尿病和糖尿病前期患者中很常见.
- 很少有研究对这些人群的睡眠结构进行了研究,特别是在没有中度至重度的SDB的情况下.
研究的目的:
- 为了检查糖尿病和糖尿病前期的成年人的睡眠结构差异,与没有这些条件的成年人相比.
- 为了在没有中度至重度睡眠呼吸暂停的情况下调查这些差异.
主要方法:
- 来自巴西Baependi心脏研究的1074名成年人的横截面研究.
- 参与者接受了在家进行的多睡眠扫描 (PSG).
- 使用禁食葡萄糖和HbA1c水平来定义糖尿病和糖尿病前期,不包括中度至重度睡眠呼吸暂停 (AHI ≥30或≥15).
主要成果:
- 患有糖尿病和糖尿病前期的参与者与没有糖尿病的参与者相比,REM睡眠持续时间显著缩短,即使经过对混因素进行调整.
- 糖尿病与较短的总睡眠时间和较长的慢波睡眠时间和百分比相关 (N3).
- 当分析仅限于轻度SDB (AHI <15) 个体时,这些发现保持一致.
结论:
- 糖尿病和糖尿病前期与睡眠结构的显著改变有关,包括减少REM睡眠和增加N3睡眠.
- 这些睡眠障碍即使没有中度至重度的睡眠呼吸暂停,也会发生.
- 这些发现突显了代谢健康和睡眠模式之间的复杂关系.
相关概念视频
Insufficient Sleep and Sleep Deprivation
167
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
167
Sleep-Wake Cycles
1.4K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.4K
Understanding Sleep
407
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
407
Pathophysiology of Diabetes
986
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
986
REM Sleep Behavior Disorder
248
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
248
Substance Use Disorders Affecting Sleep
196
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
196


