韩国慢性咳登记处的基线队列概况:一个多中心,前性,观察性研究
Eun-Jung Jo1, Ji-Hyang Lee2, Ha-Kyeong Won3
1Department of Internal Medicine, School of Medicine, Pusan National University, Busan, Korea.
Lung
|September 2, 2023
概括
韩国慢性咳登记处对610名慢性咳 (CC) 患者进行了鉴定,发现耐性或无法解释的慢性咳 (RUCC) 患者的咳持续时间更长,生活质量更差. 需要进一步研究以了解CC的进展和治疗.
科学领域:
- 肺部病理学 肺部病理学
- 临床研究 临床研究
- 流行病学 流行病学
背景情况:
- 慢性咳 (CC) 是一种常见的疾病,通常持续数年.
- 了解CC患者的特征对于改善临床管理至关重要.
- 耐火性或不明原因慢性咳 (RUCC) 是当前实践中的一个重大挑战.
研究的目的:
- 描述韩国慢性咳注册的基线队列概况.
- 在现实临床环境中研究慢性咳患者的特征和结果.
- 建立持续纵向随访CC患者的协议.
主要方法:
- 一个多中心的,前性的观察队列研究.
- 包括新转诊的CC患者和RUCC患者.
- 使用视觉模拟尺度,莱斯特咳问卷 (LCQ) 和咳过敏性问卷 (CHQ) 评估咳状态.
主要成果:
- 招募了610名患者 (66.9%是女性,平均年龄为59.0岁).
- 在RUCC患者 (28.9%) 中,咳持续时间较长 (6.0 vs. 3.0年),LCQ得分较低 (10.3 vs. 11.6).
- RUCC患者的CHQ得分更高 (9.1比8.4),表明咳过敏性增加.
结论:
- 慢性咳,特别是RUCC,显著影响生活质量,并提出未满足的临床需求.
- 目前的治疗似乎不足以控制咳的严重程度并改善患者的治疗结果.
- 纵向数据对于阐明自然史和优化慢性咳治疗策略至关重要.
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