基于抗菌机制分类的天然石灰石的分离和生物活性
Sinan Wang1, Chuang Li1, Liyan Zhang1
1School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255049, PR China.
Bioorganic & medicinal chemistry
|September 2, 2023
概括
天然石灰石表现出强大的抗菌活性,为传统抗生素提供了有希望的替代品. 本综述详细介绍了它们对抗细菌感染的机制,包括准细胞膜和生物膜.
科学领域:
- 自然产品 化学 化学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 细菌感染仍然是人类死亡的主要原因,广泛的抗生素耐药性加剧了这种情况.
- 新型抗生素的发现已经停滞不前,迫切需要替代抗菌剂.
- 天然石灰是一种类型的黄类,表现出多种生物活性,包括显著的抗菌性质.
研究的目的:
- 审查十七种天然石英的抗菌活性和机制.
- 根据它们的抗菌机制来分类天然石膏.
- 为开发新型基于石灰的抗菌疗法提供基础.
主要方法:
- 文献综述,重点关注十七种天然石英.
- 根据抗菌机制对石墨板进行分类.
- 隔离,生物活性和抗菌机制的总结.
主要成果:
- 分析了17种天然石英的抗菌潜力.
- 机制包括细菌细胞膜的破坏,对宏分子的干扰,生物膜和定数感应的抑制.
- 石为克服现有的抗生素耐药性提供了一种可行的策略.
结论:
- 天然石灰石具有多种抗菌机制,突出其治疗潜力.
- 对石灰石的进一步研究可能会导致新型抗菌药物的开发.
- 石代表了对抗耐药细菌感染的有希望的途径.
相关概念视频
Chemical Agents for Microbial Control
54
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
54
Biological Methods for Microbial Control
62
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
62
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship
2.3K
Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic...
2.3K
Antimicrobial Effectiveness
44
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
44
Gene Regulation in Microbial Communities: Quorum Sensing
39
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
39


