rs1799971多态性对死后大脑OPRM1表达和对抗精神病药物的反应的种族相关影响
Kazusa Miyahara1, Mizuki Hino2, Risa Shishido3
1Department of Disaster Psychiatry, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan.
Journal of psychiatric research
|September 2, 2023
概括
穆阿片类受体 (MOR) 基因中的rs1799971多态性影响精神分裂症风险在不同种族之间有所不同. 它还影响了MOR mRNA水平和抗精神病治疗反应,这表明了潜在的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症涉及抑制性神经元功能障碍.
- 片受体 (MOR) 调节抑制神经元,但其在精神分裂症中的作用尚不清楚.
- 在MOR基因中的rs1799971多态性对精神分裂症风险产生有争议的影响.
研究的目的:
- 评估rs1799971多态性对亚洲和欧洲人群精神分裂症风险的影响.
- 调查死后大脑中rs1799971和MOR mRNA表达之间的关系.
- 确定MOR mRNA水平,精神分裂症症状和治疗反应之间的相关性.
主要方法:
- 对超过12,000名受试者的初步元分析,以评估rs1799971对精神分裂症风险的影响.
- 分析41个死后大脑的前额叶皮和尾状核中的MOR mRNA表达.
- 基因型,mRNA水平,临床症状和抗精神病药物治疗之间的相关性分析.
主要成果:
- 在亚洲人中,rs1799971 G-基因基因降低了精神分裂症风险,但在欧洲人中增加了风险.
- 这种多态性降低了日本前额叶皮层中MOR mRNA水平.
- 前额叶皮层中MOR mRNA的增加与更高的症状得分相关,并影响了抗精神病药物的有效性.
结论:
- rs1799971多态性影响精神分裂症风险和MOR mRNA表达,影响因种族而异.
- 过度表达MOR可能与严重的精神分裂症症状有关.
- 针对MOR和rs1799971的基因定型可能为精神分裂症提供新的治疗策略,特别是抗精神病药物耐药的病例.
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