相关实验视频

Updated: Jul 17, 2025

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

在易受压力影响的小鼠中,肠道微生物群的混乱以及短链脂肪酸和炎症过程的变化

Wenjuan Han¹, Yaxin Zheng², Lan Wang²

¹Department of Psychiatry, The First Hospital of Hebei Medical University, The Mental Health Center of Hebei Medical University, The Mental Health Institute of Hebei Medical University, Shijiazhuang 050031, Hebei, China; Department of Psychiatry and Psychology, The Second Hospital of Hebei Medical University, Shijiazhuang 050005, Hebei, China.

Journal of neuroimmunology

|September 2, 2023

概括

在小鼠中,慢性压力脆弱性与肠道微生物组的变化和炎症有关. 补充短链脂肪酸 (SCFA) 通过减少海马体炎症,扭转了类似抑郁症的行为.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
精神病学是一个精神病学.

背景情况:

慢性压力会增加抑郁症的风险,但只在易受影响的个体中.
炎症是压力脆弱性的关键因素.
肠道微生物群及其代谢物,如短链脂肪酸 (SCFA),影响肠-大脑轴.

研究的目的:

研究肠道微生物组和SCFA在压力诱导的抑郁症中的作用.
探索SCFA对海马体炎症通路的影响.

主要方法:

鼠被暴露在慢性不可预测的轻度压力 (CUMS) 中,并被分类为易受伤害或弹性.
分析了便微生物组组成 (16S rRNA测序) 和SCFA水平.
评估了海马体的炎症 (细胞因子,TLR4/MYD88/NF-κB通路).
在CUMS小鼠中补充了SCFA,以观察对行为和炎症的影响.

主要成果:

易患CUMS的小鼠表现出更严重的抑郁和焦虑,改变了肠道微生物多样性,并增加了海马IL-1β和TLR4/MYD88/NF-κB通路的激活.
与对照组相比,弹性小鼠的便中SCFA水平较高.
在CUMS小鼠中,SCFA补充剂逆转了类似抑郁症的行为,并减少了海马炎症通路的激活.

结论:

肠道微生物组的改变和减少的SCFA与压力脆弱性和抑郁症有关.
通过调节肠-大脑轴和减少神经炎症,SCFA可能会减轻抑郁症.
准肠道微生物组和SCFA生产为抑郁症疾病提供了潜在的治疗策略.

关键词:

慢性压力是一种慢性压力.抑郁症抑郁症抑郁症我们的肠道微生物群.炎症炎症是一种炎症.短链脂肪酸短链脂肪酸

更多相关视频

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

Published on: July 12, 2024

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

相关概念视频

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...

Stress and Mental Health

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...