多发性硬化症与与普通人群相比更糟糕的COVID-19结果有关:基于人口的研究
Mahdi Barzegar1, Setayesh Sindarreh2, Amirreza Manteghinejad3
1Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Multiple sclerosis and related disorders
|September 2, 2023
概括
与普通人群相比,患有多发性硬化症 (MS) 的患者住院和死于COVID-19的几率更高. 这种增加的风险在患有多发性硬化症的年轻人中尤为明显.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经系统疾病.
- 了解COVID-19在患有多发性硬化症 (PLWMS) 的人群中的结果至关重要.
研究的目的:
- 为了比较PLWMS和无MS个体之间的COVID-19住院和死亡率.
- 调查COVID-19结果中的特定年龄差异.
主要方法:
- 使用伊斯法罕医学科学大学数据 (2020年1月至2021年8月) 进行了基于人口的回顾性研究.
- 包括PLWMS,COVID-19测试结果,住院和死亡的数据.
- 医院住院和死亡率的比较,根据年龄和性别进行调整.
主要成果:
- 分析了829个PLWMS和2494个COVID-19的对照.
- 调整后的分析显示,PLWMS患者住院的几率增加了56% (OR=1.56).
- 年轻的PLWMS患者的住院几率明显更高 (OR=1.699),而年长的PLWMS患者没有显示出差异.
结论:
- 与普通人群相比,PLWMS面临COVID-19住院和死亡率上升的可能性.
- 增加风险的确切原因 (MS本身与其他因素) 需要进一步调查.
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