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免疫检查点抑制剂的心胸并发症
Babina Gosangi1, Yifan Wang1, Ami N Rubinowitz1
1Yale School of Medicine, New Haven, CT 06510, United States of America.
Clinical imaging
|September 2, 2023
概括
免疫检查点抑制剂 (ICI) 改善癌症生存率,但可能导致危及生命的免疫相关不良反应 (irAEs). 放射科医生必须识别心脏和肺部毒性,这些毒性与较高的死亡率有关,需要早期检测.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 免疫治疗是一种免疫疗法.
背景情况:
- 免疫检查点抑制剂 (ICI) 代表了癌症治疗的重大进展,改善了各种恶性瘤的治疗结果.
- 虽然有效,但ICI治疗与免疫相关的不良反应 (irAEs) 有关,这些不良反应可以从轻微到危及生命的程度.
- 某些irrAEs,如肺炎和心肌炎,具有很大的死亡风险,需要及时识别.
研究的目的:
- 突出放射科医生在识别和管理与ICI治疗相关的并发症方面的关键作用.
- 审查由irAEs产生的心胸毒性特征的成像特征.
- 讨论与irAEs相关的复发性,慢性和非典型瘤反应.
主要方法:
- 审查关于免疫检查点抑制剂及其相关毒性的当前文献.
- 分析患有免疫相关不良影响的患者的成像研究结果.
- 影像检测结果与临床结果和死亡率的相关性.
主要成果:
- 艾尔艾斯的发展通常与改善患者存活率有关,这强调了它们作为治疗反应的潜在生物标志物的作用.
- 包括肺炎和心肌炎在内的心脏胸部irrAEs特别令人担忧,因为它们的死亡率很高.
- 放射科医生在早期检测这些毒性方面发挥着至关重要的作用,使得及时干预成为可能.
结论:
- 对ICI相关的毒性及其成像表现的认识对于放射科医生来说至关重要.
- 早期识别和治疗严重的irrAEs,特别是心脏和肺,可以改善患者的生存率.
- 了解非典型瘤反应和慢性IRAE有助于在ICI治疗期间全面照顾患者.
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