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在炎症性疾病中,对抗IL17治疗的反应不会受到遗传背景的强烈影响
Cong Zhang1, Konstantin Shestopaloff2, Benjamin Hollis3
1China Novartis Institutes for Bio-medical Research CO., Shanghai, China.
American journal of human genetics
|September 2, 2023
概括
在炎症性疾病中,遗传因素不能预测对抗因特鲁金-17 (IL-17) 抗体secukinumab的反应. 这一发现表明,遗传背景不会影响抗IL-17疗法的有效性.
科学领域:
- 药物遗传学 药物遗传学
- 免疫学 免疫学 免疫学
- 炎症性疾病的遗传学
背景情况:
- 对于抗类素-17 (IL-17) 单克隆抗体secuquinumab的反应在患有炎症状况的患者之间有所不同.
- 了解这种异质性的遗传基础对于在风湿病学和皮肤病学中推进精密医学至关重要.
研究的目的:
- 为了调查遗传变异是否会影响多种炎症性疾病中对secukinumab的治疗反应.
- 确定遗传因素是否有助于观察到患者对抗IL-17治疗反应的异质性.
主要方法:
- 分析了来自19项临床试验的5218个基因型个体的遗传数据.
- 在牛皮性关节炎,牛皮,性脊柱炎和类风湿性关节炎中使用疾病活性评分来评估治疗反应.
- 测试响应与常见变异之间的关联,HLA等位基因,多基因风险得分和共享遗传风险组件.
主要成果:
- 在基因变异和对secuquinumab的反应之间没有发现显著的关联.
- 常见变异,归因的HLA基因基因和多基因风险得分并不能预测治疗结果.
- 跨疾病共享的遗传风险成分也与secukinumab疗效无关.
结论:
- 遗传背景似乎不会影响抗干素-17 (IL-17) 治疗的有效性.
- 这些发现表明,seukinumab的疗效在各种遗传特征中是一致的.
- 对生物疗法在炎症性疾病的未来药物遗传学研究的影响.
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