一个新型的抑制性皮质干细胞电路,表达了Mu阿片类受体介导的突触可塑性
Braulio Munoz1, Brady K Atwood2
1Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Neuropharmacology
|September 2, 2023
概括
研究人员发现了一种新的抑制性大脑电路,将皮质连接到条纹体. 这种由类阿片受体调节的电路可能在控制酒精和药物行为方面发挥作用.
科学领域:
- 神经科学是一个神经科学.
- 神经生物学 神经生物学 神经生物学
- 成研究 研究成研究
背景情况:
- 皮质三角管回路,主要是谷氨酸,调节成行为.
- 之前的研究已经确定了前岛皮层 (AIC) 到背侧条纹体 (DLS) 激发性突触控制酒精摄入量和片受体介导激发性长期抑郁症 (MOR-LTD).
- 新出现的证据表明,一些皮层区域为背状条体提供直接的抑制输入,但AIC-DLS抑制传播仍然没有特征.
研究的目的:
- 描述AIC和DLS之间抑制性突触传输的存在和调节.
- 在这个新型电路中研究类阿片受体介导的抑制性长期抑郁症 (MOR-iLTD) 的作用.
主要方法:
- 补丁电生理学 补丁电生理学
- 视觉遗传学 视觉遗传学
- 转基因小鼠表达cre-recombinase在表达parvalbumin的抑制神经元中的表达.
主要成果:
- 预突触的类阿片受体 (MORs) 的激活会在DLS和背中状体中诱导MOR-iLTD.
- 在DLS中,中等脊髓神经元从运动皮层和AIC接收直接的抑制性突触输入.
- 使用转基因小鼠识别的皮质GABAergic神经元的特定亚型直接向DLS投射,并表现出MOR-iLTD.
结论:
- 已经确定了一个从AIC到DLS的新型GABAergic皮质地板电路.
- 这种抑制电路由MOR-iLTD进行调节.
- 这种新特征的电路可能参与调节药物和酒精消费行为.
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