血液中的重金属与胆结石之间的联系:一个横截面研究
Jia Wang1, Yu-Xin Sun2, Shuai Xiang3
1Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
The Science of the total environment
|September 2, 2023
概括
高血 (Se) 水平会增加胆结石的风险,特别是在年轻人,女性,非西班牙裔白人,不喝酒,肥胖和受过大学教育的人群中. 相反,较低的血液 (Cd) 和 (Hg) 显示了胆结石风险的降低.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 胃肠病学 胃肠病学
背景情况:
- 暴露于重金属是已知的健康风险.
- 关于血液中的重金属和胆结石形成的数据有限.
- 这项研究调查了血液中的重金属与胆结石之间的关联.
研究的目的:
- 为了检查血清重金属度和胆结石之间的关系.
- 使用来自国家健康和营养检查调查 (NHANES) 的数据.
主要方法:
- 来自NHANES的7192名参与者 (20岁以上) 的分析.
- 血清重金属通过ICP-MS测量.
- 胆结石的存在通过问卷确定.
- 进行了后勤回归,非线性,子组和灵敏度分析.
主要成果:
- 血 (Se) 的最高五分位数与胆结石风险增加相关 (OR=1.66).
- 这种关联在特定的人口结构中很突出:65岁以下,女性,非西班牙裔白人,非饮酒者,肥胖者和受过高等教育者.
- 血液中的 (Cd) 和 (Hg) 在特定度值范围内与胆结石有负相关性.
结论:
- 血 (Se) 是胆结石的独立风险因素,特别是在定义的子组中.
- 在某些范围内,血液中的 (Cd) 和 (Hg) 可能与胆结石风险降低有关.
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