怀孕期间环境暴露于pyrifos,APOE多态性和自闭症类行为风险
Judit Biosca-Brull1, Pia Basaure2, Laia Guardia-Escote2
1Universitat Rovira i Virgili, Research Group in Neurobehavior and Health (NEUROLAB), Tarragona, Spain; Universitat Rovira i Virgili, Department of Psychology and Research Center for Behavior Assessment (CRAMC), Tarragona, Spain; Universitat Rovira i Virgili, Center of Environmental, Food and Toxicological Technology (TECNATOX), Reus, Spain.
Environmental research
|September 2, 2023
概括
在小鼠中,产前暴露于pyrifos (CPF) 和酸 (VPA) 对发育和行为产生影响. 这些环境因素,以及APOE基因变异,影响自闭症类特征和焦虑,影响胆固醇系统中的基因表达.
科学领域:
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
- 遗传学 是一个遗传学.
背景情况:
- 自闭症谱系障碍 (ASD) 涉及社会和沟通缺陷,通常与焦虑同时发生.
- 环境因素如pyrifos (CPF) 和遗传因素与神经发育障碍有关.
- APOE基因多态是一种已知的遗传因素,与各种神经疾病有关.
研究的目的:
- 研究妊娠期CPF暴露和APOE多态化对沟通,早期发育和焦虑类行为的影响.
- 分析基因表达在胆固醇系统中的变化,以应对这些暴露.
- 使用酸 (VPA) 作为自闭症类行为的积极控制.
主要方法:
- 暴露于C57BL/6J和人类化的apoE3/apoE4小鼠在妊娠期间 (GD 12-18) 接触到CPF.
- 向单独一组C57BL/6J小鼠作为阳性对照给予VPA.
- 评估了沟通 (超声波发声),发育,运动活动,焦虑类行为和胆固醇基因表达.
主要成果:
- 在C57BL/6J小鼠中,产前CPF和VPA暴露导致体重减轻和眼睛打开延迟.
- 沟通和焦虑行为受到CPF和VPA治疗的不同影响.
- 观察到基因表达变化,受性别和治疗的影响,在暴露于CPF的APOE转基因小鼠中没有发现显著影响,尽管存在基因型差异.
结论:
- 孕期暴露于CPF和VPA会对沟通和焦虑行为产生明显的影响.
- 产前环境侮辱与遗传背景 (APOE多态) 相互作用,以调节神经发育结果.
- 需要进一步的研究来阐明这些观察到的对胆固醇系统和行为影响的具体机制.
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