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局部默克尔细胞癌的主要瘤部位驱动着不同的管理策略,而不会影响瘤结果
Samuel Cass1, Brandon Cope1, Andrew J Bishop2
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States.
概括
默克尔细胞癌 (MCC) 中的主要瘤部位会影响治疗,但不会影响复发率. 头部和部MCC患者接受了不同的辐射疗法和手术方法,但取得了与非头部和部MCC患者相似的结果.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 辐射瘤学 辐射瘤学
背景情况:
- 默克尔细胞癌 (MCC) 是一种具有高复发率的侵袭性皮肤癌,即使局部化.
- 主要瘤的位置显著影响治疗策略和患者的治疗结果.
研究的目的:
- 为了研究主要瘤的解剖部位如何影响治疗模式和结果在一个大队伍的默克尔细胞癌患者.
- 为了比较头部和部 (HN) 的治疗方法和复发率与非头部和部 (NHN) MCC.
主要方法:
- 对80名临床I-II期MCC患者的回顾性分析,这些患者在2014-2021年期间接受了治愈意图的治疗.
- 评估护理模式,包括手术和辅助放射治疗 (RT),基于主要瘤部位.
- 局部无复发生存率 (LRFS),节点无复发生存率 (NRFS) 和总体无复发生存率 (RFS) 的比较.
主要成果:
- 在80名患者中,42人 (53%) 患有HN瘤,38人 (47%) 患有NHN瘤. 患有HN瘤的患者不太可能接受广泛局部切除 (WLE) 和哨兵淋巴结活检 (SLNB).
- 与NHN患者相比,HN瘤患者接受了较高剂量的辅助RT,并且比NHN患者更有可能有选择性节点RT.
- 尽管管理策略不同,但3年LRFS (94%对94%),NRFS (89%对85%) 和RFS (73%对80%) 在HN和NHN队列中是相似的.
结论:
- 对初级MCC的解剖学驱动,异质的治疗方法,包括不同的RT和外科手术策略,导致优秀和可比的局部区域疾病控制.
- 在MCC中,主要瘤的解剖部位在应用适当的管理时似乎不是复发风险的重要决定因素.
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