基于粉的材料用于在胃肠道输送药物-一篇评论
1Planta Piloto de Ingeniería Química (PLAPIQUI), CONICET - Universidad Nacional del Sur (UNS), Camino La Carrindanga km 7, 8000 Bahía Blanca, Argentina; Departamento de Ingeniería Química, UNS, Avenida Alem 1253, 8000 Bahía Blanca, Argentina.
Carbohydrate polymers
|September 2, 2023
概括
基于粉的材料为药物输送系统 (DDS) 提供了一个廉价,环保的平台. 本综述探讨了基于内部刺激在胃肠道 (GIT) 中控制释放的设计.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 制药科学 制药科学
背景情况:
- 粉是一种天然的共聚物质,具有独特的物理化学特性.
- 改性粉材料越来越多地被用于药物输送系统 (DDS),因为它们的成本低,生物降解性,生物相容性和可再生性.
研究的目的:
- 审查以粉为基础的材料的设计,以进行刺激反应的药物控制释放.
- 专注于口服的DDS,根据内部刺激 (pH,温度,酶,微生物群) 针对胃肠道 (GIT).
主要方法:
- 讨论管理刺激响应材料设计的物理化学原理.
- 对DDS结构,粉修饰方法和药物释放特征之间的关系进行系统分析.
主要成果:
- 基于粉的DDS可以被设计为在GIT内对内部刺激的特定反应.
- 修改路径和DDS结构显著影响药物释放动力学.
结论:
- 基于粉的材料显示出对开发先进的,对刺激有反应的DDS用于口服的显著前景.
- 需要进一步的研究来克服挑战,并充分发挥这些材料的潜力.
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