粘合剂可注射纤维素基水凝具有快速自我愈合和持续药物释放能力,可促进伤口愈合
Lu Li1, Lixin Wang2, Xinxin Luan1
1Qingdao University of Science & Technology, Qingdao 266042, China.
Carbohydrate polymers
|September 2, 2023
概括
新的自我愈合的水凝促进伤口愈合. 这些生物相容材料具有粘附性,抗菌性质和血液静止,加速组织再生,以改善伤口护理.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 再生医学是一种再生医学.
背景情况:
- 先进的伤口需要多功能,包括自我愈合,粘附和抗菌特性,以改善愈合结果.
- 可注射水凝提供最少的侵入性应用,可以符合不规则的伤口表面.
- 基于纤维素的材料由于其生物相容性和生物降解性而具有吸引力.
研究的目的:
- 为了合成和表征新的多功能注射式自我愈合的纤维素基水凝用于伤口包裹应用.
- 评估水凝的自我愈合能力,机械性能和药物释放动力学.
- 评估体外抗菌活性和体内血静和伤口愈合功效.
主要方法:
- 合成碳甲基纤维素-移植-基二化物 (CMC-ADH) 和4-甲基酸终结聚乙烯甘醇 (PEG-FBA) 聚合物.
- 通过动态共价乙连接形成CMC-ADH/PEG-FBA水凝.
- 在体外评估凝时间,自我愈合,药物释放 (西普洛克萨) 和抗菌活性对抗阳性和阴性细菌.
- 在体内评估使用小鼠肝脏出血模型进行血液静止和全厚皮肤缺陷模型用于伤口愈合和血管生成.
主要成果:
- 在CMC-ADH/PEG-FBA水凝中实现了可调节的凝时间和优良的自我愈合特性.
- 证实了持续的药物释放和显著的体外抗菌活性对测试的细菌.
- 在体内研究表明有效的血液静止,加速伤口愈合,增强血管生成,以及良好的粘附不规则的伤口.
- 水凝创造了潮湿的环境,减少了炎症,促进了组织再生.
结论:
- 开发的多功能可注射的基于纤维素的自我愈合水凝 (CMC-ADH/PEG-FBA) 对伤口愈合有很大的前景.
- 这些水凝具有理想的特性,包括自我愈合,粘附,抗菌活性和血液静止.
- 它们促进组织再生和血管生成的能力使它们成为治疗复杂伤口的理想候选人,包括那些有出血的伤口.
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