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在rTMS之前的听觉皮层超连接性与耳改善相关.

E Kim1, H Kang1, T-S Noh2

  • 1Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.

Neurologia
|September 2, 2023
PubMed
概括

在重复性跨磁刺激 (rTMS) 之前,听觉皮层的休息状态功能连接可以预测耳治疗的成功. 左听力皮层 (A1) 的连接性增加与rTMS治疗的更好的结果有关.

关键词:
艾库芬索斯 (Acúfenos) 是一种葡萄糖.连接体瘤 (Conectoma) 是一种连接体瘤.在Connectome中使用Connectome.磁性刺激是通过头骨重复的.这就是FMRI.个体变异性的个体变化.在RMff的RMf重复性横性磁性刺激的重复性磁性刺激声 (Tinnitus) 是一种听力障碍.个人的变化 个人的变化

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科学领域:

  • 神经科学是一个神经科学.
  • 医疗成像医学成像
  • 审计系统 审计系统

背景情况:

  • 重复的横磁刺激 (rTMS) 显示出对耳的有效性有所变化.
  • 预测 tinnitus 患者的 rTMS 治疗反应仍然是一个挑战.

研究的目的:

  • 为了研究治疗前休息状态功能连接和rTMS在耳的有效性之间的关系.
  • 为了确定神经成像生物标志物来预测耳中的rTMS结果.

主要方法:

  • 在耳患者和对照者中,对左听力皮层 (A1) 和背侧前额皮层 (DLPFC) 应用了1-Hz的rTMS.
  • 在rTMS之前进行的休息状态功能磁共振成像 (fMRI).
  • 基于种子的连接分析,使用rTMS目标区域作为种子.

主要成果:

  • 与对照人群相比,声患者在听觉和前额头区域表现出功能连接的改变.
  • 左侧A1的rTMS前超连接性与耳改善有显著的相关性.
  • 在左侧DLPFC连接和耳改善之间没有发现显著的相关性.

结论:

  • 左A1连接的过同步预测了耳的成功rTMS治疗.
  • 休息状态的功能连接性可以作为定制rTMS治疗耳的生物标志物.